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Protein Engineering, Vol 10, 1-6, Copyright © 1997 by Oxford University Press


ARTICLES

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

H Nielsen, J Engelbrecht, S Brunak and G von Heijne
Department of Chemistry, Technical University of Denmark, Lyngby, Denmark.

We have developed a new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence. The method performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets. Discrimination between cleaved signal peptides and uncleaved N-terminal signal-anchor sequences is also possible, though with lower precision. Predictions can be made on a publicly available WWW server.
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Biol. Reprod.Home page
B. Nixon, R. C. Jones, and M. K. Holland
Molecular and Functional Characterization of the Rabbit Epididymal Secretory Protein 52, REP52
Biol Reprod, May 1, 2008; 78(5): 910 - 920.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
M. A. Schell, L. Lipscomb, and D. DeShazer
Comparative Genomics and an Insect Model Rapidly Identify Novel Virulence Genes of Burkholderia mallei
J. Bacteriol., April 1, 2008; 190(7): 2306 - 2313.
[Abstract] [Full Text] [PDF]


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Biol. Reprod.Home page
E. De La Chesnaye, B. Kerr, A. Paredes, H. Merchant-Larios, J. P. Mendez, and S. R. Ojeda
Fbxw15/Fbxo12J Is an F-Box Protein-Encoding Gene Selectively Expressed in Oocytes of the Mouse Ovary
Biol Reprod, April 1, 2008; 78(4): 714 - 725.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
S. Kutter, R. Buhrdorf, J. Haas, W. Schneider-Brachert, R. Haas, and W. Fischer
Protein Subassemblies of the Helicobacter pylori Cag Type IV Secretion System Revealed by Localization and Interaction Studies
J. Bacteriol., March 15, 2008; 190(6): 2161 - 2171.
[Abstract] [Full Text] [PDF]


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Brief Funct Genomic ProteomicHome page
C. Ansong, S. O. Purvine, J. N. Adkins, M. S. Lipton, and R. D. Smith
Proteogenomics: needs and roles to be filled by proteomics in genome annotation
Brief Funct Genomic Proteomic, March 10, 2008; (2008) eln010v1.
[Abstract] [Full Text] [PDF]


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J Exp BotHome page
S. Dhaubhadel, M. Farhangkhoee, and R. Chapman
Identification and characterization of isoflavonoid specific glycosyltransferase and malonyltransferase from soybean seeds
J. Exp. Bot., March 2, 2008; (2008) ern046v2.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
Y.-M. Hsiao, M.-H. Zheng, R.-M. Hu, T.-C. Yang, and Y.-H. Tseng
Regulation of the pehA gene encoding the major polygalacturonase of Xanthomonas campestris by Clp and RpfF
Microbiology, March 1, 2008; 154(3): 705 - 713.
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Appl. Environ. Microbiol.Home page
M. A. Soderberg and N. P. Cianciotto
A Legionella pneumophila Peptidyl-Prolyl cis-trans Isomerase Present in Culture Supernatants Is Necessary for Optimal Growth at Low Temperatures
Appl. Envir. Microbiol., March 1, 2008; 74(5): 1634 - 1638.
[Abstract] [Full Text] [PDF]


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DNA ResHome page
T. Goto, A. Yamashita, H. Hirakawa, M. Matsutani, K. Todo, K. Ohshima, H. Toh, K. Miyamoto, S. Kuhara, M. Hattori, et al.
Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
DNA Res, February 7, 2008; (2008) dsm030v1.
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MicrobiologyHome page
Y. Lequette, E. Lanfroy, V. Cogez, J.-P. Bohin, and J.-M. Lacroix
Biosynthesis of osmoregulated periplasmic glucans in Escherichia coli: the membrane-bound and the soluble periplasmic phosphoglycerol transferases are encoded by the same gene
Microbiology, February 1, 2008; 154(2): 476 - 483.
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MicrobiologyHome page
C. Hamsten, J. Westberg, G. Bolske, R. Ayling, M. Uhlen, and A. Persson
Expression and immunogenicity of six putative variable surface proteins in Mycoplasma mycoides subsp. mycoides SC
Microbiology, February 1, 2008; 154(2): 539 - 549.
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GeneticsHome page
N. J. Nadeau, F. Minvielle, S. Ito, M. Inoue-Murayama, D. Gourichon, S. A. Follett, T. Burke, and N. I. Mundy
Characterization of Japanese Quail yellow as a Genomic Deletion Upstream of the Avian Homolog of the Mammalian ASIP (agouti) Gene
Genetics, February 1, 2008; 178(2): 777 - 786.
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Plant CellHome page
M. Leroch, H. E. Neuhaus, S. Kirchberger, S. Zimmermann, M. Melzer, J. Gerhold, and J. Tjaden
Identification of a Novel Adenine Nucleotide Transporter in the Endoplasmic Reticulum of Arabidopsis
PLANT CELL, February 1, 2008; 20(2): 438 - 451.
[Abstract] [Full Text] [PDF]


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Mol Biol EvolHome page
M. D. Dean, J. M. Good, and M. W. Nachman
Adaptive Evolution of Proteins Secreted during Sperm Maturation: An Analysis of the Mouse Epididymal Transcriptome
Mol. Biol. Evol., February 1, 2008; 25(2): 383 - 392.
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J. Biol. Chem.Home page
R. Iijima, T. Kunieda, S. Yamaguchi, H. Kamigaki, I. Fujii-Taira, K. Sekimizu, T. Kubo, S. Natori, and K. J. Homma
The Extracellular Adenosine Deaminase Growth Factor, ADGF/CECR1, Plays a Role in Xenopus Embryogenesis via the Adenosine/P1 Receptor
J. Biol. Chem., January 25, 2008; 283(4): 2255 - 2264.
[Abstract] [Full Text] [PDF]


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Infect. Immun.Home page
A. M. Pollard, K. N. Onatolu, L. Hiller, K. Haldar, and L. J. Knoll
Highly Polymorphic Family of Glycosylphosphatidylinositol-Anchored Surface Antigens with Evidence of Developmental Regulation in Toxoplasma gondii
Infect. Immun., January 1, 2008; 76(1): 103 - 110.
[Abstract] [Full Text] [PDF]


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Appl. Environ. Microbiol.Home page
Y. Umemoto, R. Onishi, and T. Araki
Cloning of a Novel Gene Encoding -1,3-Xylosidase from a Marine Bacterium, Vibrio sp. Strain XY-214, and Characterization of the Gene Product
Appl. Envir. Microbiol., January 1, 2008; 74(1): 305 - 308.
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J BiochemHome page
H. Nakai, S. Tanizawa, T. Ito, K. Kamiya, Y.-M. Kim, T. Yamamoto, K. Matsubara, M. Sakai, H. Sato, T. Imbe, et al.
Function-unknown Glycoside Hydrolase Family 31 Proteins, mRNAs of which were Expressed in Rice Ripening and Germinating Stages, are {alpha}-Glucosidase and {alpha}-Xylosidase
J. Biochem., October 1, 2007; 142(4): 491 - 500.
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Genome ResHome page
N. Gupta, S. Tanner, N. Jaitly, J. N. Adkins, M. Lipton, R. Edwards, M. Romine, A. Osterman, V. Bafna, R. D. Smith, et al.
Whole proteome analysis of post-translational modifications: Applications of mass-spectrometry for proteogenomic annotation
Genome Res., September 1, 2007; 17(9): 1362 - 1377.
[Abstract] [Full Text] [PDF]


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J Exp BotHome page
J. J. Reina, C. Guerrero, and A. Heredia
Isolation, characterization, and localization of AgaSGNH cDNA: a new SGNH-motif plant hydrolase specific to Agave americana L. leaf epidermis
J. Exp. Bot., August 1, 2007; 58(11): 2717 - 2731.
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Genes Dev.Home page
K. Hara, R. Kajita, K. U. Torii, D. C. Bergmann, and T. Kakimoto
The secretory peptide gene EPF1 enforces the stomatal one-cell-spacing rule
Genes & Dev., July 15, 2007; 21(14): 1720 - 1725.
[Abstract] [Full Text] [PDF]



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