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Protein Engineering, Vol. 14, No. 10, 735-745, October 2001
© 2001 Oxford University Press

Signature of quaternary structure in the sequences of legume lectins

N. Manoj and K. Suguna,1

Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560 012, India

Legume lectins exhibit a wide variety of oligomerization and sugar specificity while retaining the characteristic jelly-roll tertiary fold. An attempt has been made here to find whether this diversity is reflected in their primary structures by constructing phylogenetic trees. Dendrograms based on sequence alignment showed clustering related to the oligomeric nature of legume lectins. Though the clustering primarily follows the oligomeric states, it also appears to correlate with different sugar specificities indicating an interdependence of these two properties. Analysis of the structure-based alignment and the alignment of the sequences of the carbohydrate-binding loops alone also revealed the same features. By a close examination of the interfaces of the various oligomers it was also possible, in some cases, to pinpoint a few key residues responsible for the stabilization of the interfaces.


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