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Protein Engineering, Vol. 16, No. 1, 11-18, January 2003
© 2003 Oxford University Press

HLA-A3 supermotif defined by quantitative structure–activity relationship analysis

Pingping Guan1, Irini A. Doytchinova and Darren R. Flower

Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK

1 To whom correspondence should be addressed. E-mail: pingping.guan{at}jenner.ac.uk

Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each of the 20 amino acids at each position of the peptide on binding was studied. A refined A3 supertype motif was defined in the study.


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