Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mott, R.F.
Right arrow Articles by Curnow, R.N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mott, R.F.
Right arrow Articles by Curnow, R.N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Protein Engineering vol. 4 no. 2 pp. 149-154, 1990
© 1990 Oxford University Press

RESEARCH-ARTICLE

Tests for the statistical significance of protein sequence similarities in data-bank searches

R.F. Mott1, T.B.L. Kirkwood and R.N. Curnow2

Laboratory of Mathematical Biology. National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 IAA 2Department of Applied Statistics. University of Reading Whiteknights. Reading R06 2AN, UK

1To whom correspondence should be addressed

A suite of tests to evaluate the statistical significance of protein sequence similarities is developed for use in data bank searches. The tests are based on the Wilbur — Lipman word-search algorithm, and take into account the sequence lengths and compositions, and optionally the weighting of amino acid matches. The method is extended to allow for the existence of a sequence insertion/deletion within the region of similarity. The accuracy of statistical distributions underlying the tests is validated using randomly generated sequences and real sequences selected at random from the data banks. A computer program to perform the tests is briefly described.

Keywords: data-bank searches/sequence similarity/statistical significance/Wilbur — Lipman word-search algorithm

Received June 13, 1990; accepted September 26, 1990.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.