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Protein Engineering vol. 6 no. 1 pp. 59-64, 1993
© 1993 Oxford University Press

RESEARCH-ARTICLE

Modeling of transmembrane seven helix bundles

Philippe Cronet, Chris Sander and Gert Vriend

EMBL D-6900 Heidelberg, Germany

Transmembrane seven helix bundles form a large family of membrane inserted receptors and are responsible for a wide range of biological functions. Experimental data suggest that their overall structure is similar to bacteriorhodopsin. We describe here a new approach for the modeling of transmembrane seven helix bundles based on statistically derived environmental preference parameters combined with experimentally determined features of the receptors. The method was used to create a model for the human ß2-adrenoreceptor. This model is physically plausible, is in reasonable agreement with experimental data and may be helpful in planning new receptor engineering experiments.

Keywords: ß2-adrenoreceptor/bacteriorhodopsin/protein structure prediction/receptor/sequence-structure alignment

Received June 25, 1992; accepted October 28, 1992.


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