Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Suzuki, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Protein Engineering vol. 8 no. 1 pp. 1-4, 1995
© 1995 Oxford University Press

RESEARCH-ARTICLE

DNA recognition by a ß-sheet

Masashi Suzuki

MRC Laboratory of Molecular Biology Hills Road, Cambridge, CB2 2QH, UK

DNA recognition by a ß-sheet is discussed in the light of crystal structures of the MetJ and Arc repressors. The DNA binding geometry of a ß-sheet can be understood in terms of (i) close fitting of the two surfaces and (ii) matching of residue and base positions. A ß-sheet is not entirely flat but has a curvature. A ß-sheet of the Met-Arc family faces the DNA major groove with its convex surface; the local DNA major groove is deepest at the centre. The ß-sheet follows 6 bp; every two residues face the DNA and the first and fifth residues, which are separated by 13.2 Å, bind, respectively, to the third and sixth bases, which are separated by 13.5 Å, on the same DNA strand.

Keywords: Arc/MetJ/Mnt/Tra Y

Received July 5, 1994; revised July 27, 1994; accepted August 3, 1994.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
D. Gu, Y. Zhou, V. Kallhoff, B. Baban, J. J. Tanner, and D. F. Becker
Identification and Characterization of the DNA-binding Domain of the Multifunctional PutA Flavoenzyme
J. Biol. Chem., July 23, 2004; 279(30): 31171 - 31176.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.