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Protein Engineering, Vol. 12, No. 12, 1029-1030, December 1999
© 1999 Oxford University Press

COMMUNICATIONS

Rational structural genomics: affirmative action for ORFans and the growth in our structural knowledge

Daniel Fischer1

Faculty of Natural Science, Department of Mathematics and Computer Science, Ben Gurion University, Beer-Sheva 84015, Israel


   Introduction
 
The determination of the complete genome sequences of organisms is producing an avalanche of protein sequences awaiting further structural and functional interpretation. Only a small fraction of the proteins encoded in these genomes has been experimentally studied, but putative functions for roughly 70% of the ORFs can be assigned via homology with characterized proteins in the databases. Similarly, although only a very small number of structures have been determined for these proteins, putative three-dimensional (3D) structures can currently be assigned to roughly 30% of the ORFs using fold assignment computational methods. Here I address the following questions. How . . . [Full Text of this Article]


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