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Protein Engineering, Vol. 12, No. 3, 185-186, March 1999
© 1999 Oxford University Press

Communication

Comment on: `The entropy cost of protein association'

M. Karplus1,2 and J. Janin3

1 Laboratoire de Chimie Biophysique, ISIS, Institut le Bel, Universite Louis Pasteur, 67000 Strasbourg, France, 2 Department of Chemistry, Harvard University, Cambridge, MA 02138, USA and 3 Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Université d'Orsay, 91198 Gif-sur-Yvette, France

An understanding of the origin of the entropy loss involved in association processes (protein–protein or protein–ligand) is important for an interpretation of the many equilibria that play a role in biology. Although the total entropy change on association can be determined by measuring the transition temperature and associated enthalpy change (Privalov et al., 1995Go), interpretation of the results is hindered by the fact that there are several partially cancelling contributions [Tidor and Karplus, 1993 (TK)]. The loss of three translations and . . . [Full Text of this Article]

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