Protein Engineering, Vol. 12, No. 1, 1,
January 1999
© 1999 Oxford University Press
LETTER |
Protein Engineering paper cited onto Red Hot Research list
Dear ReadersWhen a single paper published in Protein Engineering catches the attention of the academic community in a big way, it brings great satisfaction to the Editors. When that paper makes it into the red-hot citation category1, it is a sufficiently rare event as to warrant a small celebration and a public congratulation to the authors. The paper described methods to predict the positions of protein signal and sorting sequences in a variety of genes derived from a number of species (Nielsen et al.,1997, 10, 1–62). In this issue the authors return with a reprise in the form of a short review of the current status of this work.
During 1999, Protein Engineering will undergo some changes. In a market where journal consolidation and merger are rife, Protein Engineering is looking to retain its individuality — its niche role — in what is still a vibrant area of protein science. The Editors are aware, however, of the need to constantly improve the journal's procedures, and more importantly, its impact. Several of the changes to be introduced will be cosmetic, while others will be more radical.
In Spring, the journal will go electronic. Its Web site will be considerably enhanced with advance notice of papers in press being posted each month and other useful features.
A subject that is always of concern to authors is the length of the refereeing procedure. This is a difficult problem, since we are so reliant on the goodwill of our scientific colleagues. However, we will be introducing some new procedures here which we think will result in significant improvement in time to publication.
Above all, we rely on you the scientific community, our suppliers, our academic resource. We very much hope that, as we seek to take the journal to its next stage of development, you will continue to see it as a beacon in a sea of post-genomic science. For our part we will strive towards ever higher quality for the papers we publish.
We wish you a happy and productive new year.
The Editors
Notes
1The Red Hot Research Papers of 1997, Science Watch, March/April 1998. (Source: ISI's Hot Papers Database). The paper of Nielson, et al. was 31 on the list, with 27 citations. As the journal went to press the citations had reached 164. 
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
Henrik Nielsen, Jacob Engelbrecht, Søren Brunak and Gunnar von Heijne
We have developed a new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence. The method performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets. Discrimination between cleaved signal peptides and uncleaved N-terminal signal-anchor sequences is also possible, though with lower precision. Predictions can be made on a publicly available WWW server.
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