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Protein Engineering, Vol. 12, No. 12, 1051-1054, December 1999
© 1999 Oxford University Press

The bottom line for prediction of residue solvent accessibility

C.J. Richardson1 and D.J. Barlow

Pharmacy Department, King's College London, Manresa Road, London SW3 6LX, UK

A simple method of predicting residue solvent accessibilities in proteins is described, with the intention that it should be used as a baseline by which more sophisticated approaches to prediction can be judged. Comparison with existing methods of predicting residue burial reveals that their performance is often little better than that of the baseline method. The problem of comparing different prediction methods is shown to be complicated by the proliferation of different schemes for classifying residue burial.

Keywords: protein structure prediction/solvent accessibility

1 To whom correspondence should be addressed. Email: foop{at}sg4.pcy.kcl.ac.uk


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