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Protein Engineering, Vol. 13, No. 12, 819-824, December 2000
© 2000 Oxford University Press

WAM: an improved algorithm for modelling antibodies on the WEB

Nicholas R.J. Whitelegg and Anthony R. Rees,1

Centre for Protein Analysis and Design,University of Bath, Claverton Down, Bath BA2 7AY, UK

An improved antibody modelling algorithm has been developed which incorporates significant improvements to the earlier versions developed by Martin et al. (1989, 1991), Pedersen et al. (1992) and Rees et al. (1996) and known as AbM (Oxford Molecular). The new algorithm, WAM (for Web antibody modelling), has been launched as an online modelling service and is located at URL http://antibody.bath.ac.uk. Here we provide a summary only of the important features of WAM. Readers interested in further details are directed to the website, which gives extensive background information on the methods employed. A brief description of the rationale behind some of the newer methodology (specifically, the knowledge-based screens) is also given.


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