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Protein Engineering, Vol. 15, No. 9, 713-715, September 2002
© 2002 Oxford University Press

COMMUNICATION

A study on the correlation of G-protein-coupled receptor types with amino acid composition

David W. Elrod1 and Kuo-Chen Chou

Computer-Aided Drug Discovery, Pharmacia, MI 49007-4940, USA

G-protein-coupled receptors have become a target in utilizing bioinformatics and genomics technology to facilitate drug discovery for psychiatric diseases. In this study the covariant-discriminant algorithm [Chou and Elrod (1999) Protein Eng., 12, 107–118] has been used to analyze the correlation between the types of G-protein-coupled receptors and the amino acid composition. It has been found that different types of G-protein-coupled receptors are quite closely correlated with the amino acid composition, implying that the types of G-protein-coupled receptors are predictable to a considerably accurate extent if a good training data set can be established for that purpose. The method derived here can be also used to do preliminary classification of orphan G-protein-coupled receptors. This will significantly expedite the process of identifying proper G-protein-coupled receptors for drug discovery.


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