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Protein Engineering, Vol. 16, No. 3, 157-160, March 2003
© 2003 Oxford University Press

COMMUNICATION

The 2002 Olympic Games of Protein Structure Prediction

Daniel Fischer1,2 and Leszek Rychlewski3

1 Bioinformatics, Department of Computer Science, Ben Gurion University, Beer-Sheva 84015, Israel and 3 BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan, Poland

2 To whom correspondence should be addressed. E-mail: dfischer{at}cs.bgu.ac.il

The summer of every even year is considered by the protein structure prediction community as the Olympic Games season, because in addition to a number of continuous benchmarking experiments such as LiveBench, much effort is invested in the blind prediction experiments CASP and CAFASP. Here we report the major advances registered in the field since the last Games of 2000, as measured by the recently completed LiveBench-4 experiment. These results provide a timely measure of the capabilities of current methods and of their expected performance in the upcoming CASP-5 and CAFASP-3 experiments. We also describe the initiation of the two new, community-wide experiments, PDB-CAFASP and MR-CAFASP. These new experiments extend the scope of previous efforts and may have important implications for structural genomics.


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