Skip Navigation


PEDS Advance Access originally published online on March 21, 2007
Protein Engineering Design and Selection 2007 20(4):155-161; doi:10.1093/protein/gzm008
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/4/155    most recent
gzm008v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chockalingam, K.
Right arrow Articles by Banta, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chockalingam, K.
Right arrow Articles by Banta, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

Design and application of stimulus-responsive peptide systems

Karuppiah Chockalingam1, Mark Blenner1 and Scott Banta1,2

1 Department of Chemical Engineering, Columbia University in the City of New York, 820 Mudd, MC4721, 500 W. 120th Street, New York, NY 10027, USA

2 To whom correspondence should be addressed. E-mail: sbanta{at}cheme.columbia.edu

The ability of peptides and proteins to change conformations in response to external stimuli such as temperature, pH and the presence of specific small molecules is ubiquitous in nature. Exploiting this phenomenon, numerous natural and designed peptides have been used to engineer stimulus-responsive systems with potential applications in important research areas such as biomaterials, nanodevices, biosensors, bioseparations, tissue engineering and drug delivery. This review describes prominent examples of both natural and designed synthetic stimulus-responsive peptide systems. While the future looks bright for stimulus-responsive systems based on natural and rationally engineered peptides, it is expected that the range of stimulants used to manipulate such systems will be significantly broadened through the use of combinatorial protein engineering approaches such as directed evolution. These new proteins and peptides will continue to be employed in exciting and high-impact research areas including bionanotechnology and synthetic biology.

Keywords: conformational changes/stimulus-responsive peptides/bionanotechnology

Received December 4, 2006; revised January 10, 2007; accepted January 18, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
I. R. Wheeldon, J. W. Gallaway, S. C. Barton, and S. Banta
Bioelectrocatalytic hydrogels from electron-conducting metallopolypeptides coassembled with bifunctional enzymatic building blocks
PNAS, October 7, 2008; 105(40): 15275 - 15280.
[Abstract] [Full Text] [PDF]

Home page
 Protein Eng Des SelHome page
M. Casali, S. Banta, C. Zambonelli, Z. Megeed, and M. L. Yarmush
Site-directed mutagenesis of the hinge peptide from the hemagglutinin protein: enhancement of the pH-responsive conformational change
Protein Eng. Des. Sel., June 1, 2008; 21(6): 395 - 404.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.