Protein Engineering Design and Selection

Letter from the Editors:

Anthony R. Rees and Gregory A. Petsko

Letter from the Editors
Protein Eng. 1986 1: 1; doi:10.1093/protein/1.1.1 [PDF] [Request Permissions]  

Commentaries:

R Wetzel

What is protein engineering?
Protein Eng. 1986 1: 3-5; doi:10.1093/protein/1.1.3 [PDF] [Request Permissions]  

R. Wetzel

Specificity of tRNA charging in Tyr-tRNA synthetase
Protein Eng. 1986 1: 5-6; doi:10.1093/protein/1.1.5 [PDF] [Request Permissions]  

REVIEW:

Robin J. Leatherbarrow and Alan R. Fersht

Protein engineering
Protein Eng. 1986 1: 7-16; doi:10.1093/protein/1.1.7 [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

T. Doi, T. Tokunaga, E. Ohtsuka, Y. Hiraki, F. Suzuki, and M. Ikehara

Expression of the amino terminal part of synthetic human growth hormone gene and somatomedin-like activity of expressed protein
Protein Eng. 1986 1: 17-21; doi:10.1093/protein/1.1.17 [Abstract] [PDF] [Request Permissions]  

Carmichael J.A. Wallace and Blaise E. Corthésy

Protein engineering of cytochrome c by semisynthesis: substitutions at Glutamic acid 66
Protein Eng. 1986 1: 23-27; doi:10.1093/protein/1.1.23 [Abstract] [PDF] [Request Permissions]  

S. Jallat, D. Carvallo, L.H. Tessier, D. Roecklin, C. Roitsch, F. Ogushi, R.G. Crystal, and M. Courtney

Altered specificities of genetically engineered ₁ antitrypsin variants
Protein Eng. 1986 1: 29-35; doi:10.1093/protein/1.1.29 [Abstract] [PDF] [Request Permissions]  

Robert A. Love and Robert M. Stroud

The crystal structure of -bungarotoxin at 2.5 Å resolution: relation to solution structure and binding to acetylcholine receptor
Protein Eng. 1986 1: 37-46; doi:10.1093/protein/1.1.37 [Abstract] [PDF] [Request Permissions]  

Susan B. Masters, Robert M. Stroud, and Henry R. Bourne

Family of G protein chains: amphipathic analysis and predicted structure of functional domains
Protein Eng. 1986 1: 47-54; doi:10.1093/protein/1.1.47 [Abstract] [PDF] [Request Permissions]  

C. Murali and E.H. Creaser

Protein engineering of alcohol dehydrogenase — 1. Effects of two amino acid changes in the active site of yeast ADH-1
Protein Eng. 1986 1: 55-57; doi:10.1093/protein/1.1.55 [Abstract] [PDF] [Request Permissions]  

S. Roberts and A.R. Rees

The cloning and expression of an anti-peptide antibody: a system for rapid analysis of the binding properties of engineered antibodies
Protein Eng. 1986 1: 59-65; doi:10.1093/protein/1.1.59 [Abstract] [PDF] [Request Permissions]  

David A. Mead, Elzbieta Szczesna-Skorupa, and Byron Kemper

Single-stranded DNA ‘blue’ T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering
Protein Eng. 1986 1: 67-74; doi:10.1093/protein/1.1.67 [Abstract] [PDF] [Request Permissions]  

PROTOCOLS:

Mohinder Singh, Shaun Heaphy, and Michael J. Gait

Oligonucleotide-directed misincorporation mutagenesis on singlestranded DNA templates
Protein Eng. 1986 1: 75-76; doi:10.1093/protein/1.1.75 [PDF] [Request Permissions]  

Arthur M. Lesk, Michael Levitt, and Cyrus Chothia

Alignment of the amino acid sequences of distantly related proteins using variable gap penalties
Protein Eng. 1986 1: 77-78; doi:10.1093/protein/1.1.77 [PDF] [Request Permissions]  

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