Protein Engineering Design and Selection

ARTICLES:

RB Sessions, V Dewar, AR Clarke, and JJ Holbrook

A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia
Protein Eng. 1997 10: 301-306; doi:10.1093/protein/10.4.301 [PDF] [Request Permissions]  

G Chelvanayagam, A Eggenschwiler, L Knecht, GH Gonnet, and SA Benner

An analysis of simultaneous variation in protein structures
Protein Eng. 1997 10: 307-316; doi:10.1093/protein/10.4.307 [Abstract] [PDF] [Request Permissions]  

WP Hu, A Godzik, and J Skolnick

Sequence-structure specificity--how does an inverse folding approach work?
Protein Eng. 1997 10: 317-331; doi:10.1093/protein/10.4.317 [Abstract] [PDF] [Request Permissions]  

RB Russell and MJ Sternberg

Two new examples of protein structural similarities within the structure-function twilight zone
Protein Eng. 1997 10: 333-338; doi:10.1093/protein/10.4.333 [Abstract] [PDF] [Request Permissions]  

M Ota and K Nishikawa

Assessment of pseudo-energy potentials by the best-five test: a new use of the three-dimensional profiles of proteins
Protein Eng. 1997 10: 339-351; doi:10.1093/protein/10.4.339 [Abstract] [PDF] [Request Permissions]  

K Ogata and H Umeyama

Prediction of protein side-chain conformations by principal component analysis for fixed main-chain atoms
Protein Eng. 1997 10: 353-359; doi:10.1093/protein/10.4.353 [Abstract] [PDF] [Request Permissions]  

P Tuffery, C Etchebest, and S Hazout

Prediction of protein side chain conformations: a study on the influence of backbone accuracy on conformation stability in the rotamer space
Protein Eng. 1997 10: 361-372; doi:10.1093/protein/10.4.361 [Abstract] [PDF] [Request Permissions]  

J Higo and H Umeyama

Protein dynamics determined by backbone conformation and atom packing
Protein Eng. 1997 10: 373-380; doi:10.1093/protein/10.4.373 [Abstract] [PDF] [Request Permissions]  

LV Mello, DM van Aalten, and JB Findlay

Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics
Protein Eng. 1997 10: 381-387; doi:10.1093/protein/10.4.381 [Abstract] [PDF] [Request Permissions]  

TP Walsh and GH Grant

Computer modelling of the receptor-binding domains of VEGF and PIGF
Protein Eng. 1997 10: 389-398; doi:10.1093/protein/10.4.389 [Abstract] [PDF] [Request Permissions]  

M Roberge, C Dupont, R Morosoli, F Shareck, and D Kluepfel

Asparagine-127 of xylanase A from Streptomyces lividans, a key residue in glycosyl hydrolases of superfamily 4/7: kinetic evidence for its involvement in stabilization of the catalytic intermediate
Protein Eng. 1997 10: 399-403; doi:10.1093/protein/10.4.399 [Abstract] [PDF] [Request Permissions]  

EC Wang, SH Hung, M Cahoon, and L Hedstrom

The role of the Cys191-Cys220 disulfide bond in trypsin: new targets for engineering substrate specificity
Protein Eng. 1997 10: 405-411; doi:10.1093/protein/10.4.405 [Abstract] [PDF] [Request Permissions]  

M Kurasaki, R Yamaguchi, AR Linde Arias, M Okabe, and Y Kojima

Significance of alpha-fragment of metallothionein in cadmium binding
Protein Eng. 1997 10: 413-416; doi:10.1093/protein/10.4.413 [Abstract] [PDF] [Request Permissions]  

H Zhu, J Anchin, K Ramnarayan, J Zheng, T Kawai, S Mong, and ME Wolff

Analysis of high-affinity binding determinants in the receptor binding epitope of basic fibroblast growth factor
Protein Eng. 1997 10: 417-421; doi:10.1093/protein/10.4.417 [Abstract] [PDF] [Request Permissions]  

AA Kortt, M Lah, GW Oddie, CL Gruen, JE Burns, LA Pearce, JL Atwell, AJ McCoy, GJ Howlett, DW Metzger, RG Webster, and PJ Hudson

Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero- residue linker a trimer
Protein Eng. 1997 10: 423-433; doi:10.1093/protein/10.4.423 [Abstract] [PDF] [Request Permissions]  

L Nieba, A Honegger, C Krebber, and A Pluckthun

Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment
Protein Eng. 1997 10: 435-444; doi:10.1093/protein/10.4.435 [Abstract] [PDF] [Request Permissions]  

SM Kipriyanov, G Moldenhauer, AC Martin, OA Kupriyanova, and M Little

Two amino acid mutations in an anti-human CD3 single chain Fv antibody fragment that affect the yield on bacterial secretion but not the affinity
Protein Eng. 1997 10: 445-453; doi:10.1093/protein/10.4.445 [Abstract] [PDF] [Request Permissions]  

S Kim, J Baum, and S Anderson

Production of correctly folded recombinant [13C, 15N]-enriched guinea pig [Val90]-alpha-lactalbumin
Protein Eng. 1997 10: 455-462; doi:10.1093/protein/10.4.455 [Abstract] [PDF] [Request Permissions]  

DL Newton, Y Xue, L Boque, A Wlodawer, HF Kung, and SM Rybak

Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: potential for cancer therapy
Protein Eng. 1997 10: 463-470; doi:10.1093/protein/10.4.463 [Abstract] [PDF] [Request Permissions]  

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