Cover design Molecular model showing a substrate (yellow) bound to the active site of human neutrophil elastase (magenta). A substrate histidine (red) at the P2 but not P1 position can be virtually superimposed upon the catalytic histidine, H57 (green), and mimic the interactions of H57 with the other members of the catalytic triad, S195 and D102 (green). The P2 substrate histidine can also substitute functionally for the catalytic histidine. For further details see Dall'Acqua et al., pages 981-987. This figure was prepared with the generous help of Dr Leonard G.Presta.
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