Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Matthew J. Betts and Michael J.E. Sternberg

An analysis of conformational changes on protein–protein association: implications for predictive docking
Protein Eng. 1999 12: 271-283; doi:10.1093/protein/12.4.271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Olivier Roche and Martin J. Field

Simulations of the T R conformational transition in aspartate transcarbamylase
Protein Eng. 1999 12: 285-295; doi:10.1093/protein/12.4.285 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Raj Gill, Chandra Verma, Brenda Wallach, Birgitte Ursø, Jim Pitts, Axel Wollmer, Pierre De Meyts, and Steve Wood

Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding
Protein Eng. 1999 12: 297-303; doi:10.1093/protein/12.4.297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vladimir M. Tseitin and Gregory V. Nikiforovich

Isolated transmembrane helices arranged across a membrane: computational studies
Protein Eng. 1999 12: 305-311; doi:10.1093/protein/12.4.305 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anne-Typhaine Bouthors, Jean Delettré, Pierre Mugnier, Vincent Jarlier, and Wladimir Sougakoff

Site-directed mutagenesis of residues 164, 170, 171, 179, 220, 237 and 242 in PER-1 ß-lactamase hydrolysing expanded-spectrum cephalosporins
Protein Eng. 1999 12: 313-318; doi:10.1093/protein/12.4.313 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter Stenlund and Lena A.E. Tibell

Chimeras of human extracellular and intracellular superoxide dismutases. Analysis of structure and function of the individual domains
Protein Eng. 1999 12: 319-325; doi:10.1093/protein/12.4.319 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yuji Ito, Ryota Kuroki, Yoko Ogata, Yoshio Hashimoto, Kazuhisa Sugimura, and Taiji Imoto

Analysis of a catalytic pathway via a covalent adduct of D52E hen egg white mutant lysozyme by further mutation
Protein Eng. 1999 12: 327-331; doi:10.1093/protein/12.4.327 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas J. Begley and Richard P. Cunningham

Methanobacterium thermoformicicum thymine DNA mismatch glycosylase: conversion of an N-glycosylase to an AP lyase
Protein Eng. 1999 12: 333-340; doi:10.1093/protein/12.4.333 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zhen Wu, Mark Demma, Corey L. Strickland, Rosalinda Syto, Hung V. Le, William T. Windsor, and Patricia C. Weber

High-level expression, purification, kinetic characterization and crystallization of protein farnesyltransferase ß-subunit C-terminal mutants
Protein Eng. 1999 12: 341-348; doi:10.1093/protein/12.4.341 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gang Chen, Ido Dubrawsky, Patina Mendez, George Georgiou, and Brent L. Iverson

In vitro scanning saturation mutagenesis of all the specificity determining residues in an antibody binding site
Protein Eng. 1999 12: 349-356; doi:10.1093/protein/12.4.349 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Simon Delagrave, John Catalan, Charles Sweet, Glenn Drabik, Andrew Henry, Anthony Rees, Thomas P. Monath, and Farshad Guirakhoo

Effects of humanization by variable domain resurfacing on the antiviral activity of a single-chain antibody against respiratory syncytial virus
Protein Eng. 1999 12: 357-362; doi:10.1093/protein/12.4.357 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sophie Déret, Luc Denoroy, Marc Lamarine, Ruben Vidal, Béatrice Mougenot, Blas Frangione, Fred J. Stevens, Pierre M. Ronco, and Pierre Aucouturier

Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals
Protein Eng. 1999 12: 363-369; doi:10.1093/protein/12.4.363 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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