Cover design The figure shows a space-filling model of ß-lactamase, highlighting in red the two residues that were mutated to relocate the carboxylate group responsible for deacylation (E166Q and N170D). The catalytic serine residue is shown in pink and the hydrolytic water molecule in blue. (The figure was generated using the computer program Raster3D written by David Bacon). For further details, see Chen and Herzberg, pages 573-579.
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