Cover.
Crystal structure of parental T84.66 anti-CEA diabody (top) (Carmichael et al., J. Mol. Biol., 326, 341, 2003) and a model of the covalent anti-CEA cys-diabody (bottom). Alpha carbon traces are shown. Light chain variable region (light green), heavy chain variable region (dark green), complementarity determining regions (white), inter-domain linker (magenta), C-terminal gly (blue) and cys (yellow) residues are shown. In the model, the Fv regions have been rotated to allow the cys residues to form disulfide bridge. For further details, see Olafsen et al., pages 21-27.
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