Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Kin-Ming Lo, Jinyang Zhang, Yaping Sun, Bo Morelli, Yan Lan, Scott Lauder, Beatrice Brunkhorst, Gordon Webster, Sophie Hallakou-Bozec, Lilliane Doaré, and Stephen D. Gillies

Engineering a pharmacologically superior form of leptin for the treatment of obesity
PEDS Advance Access published on March 14, 2005
Protein Engineering, Design and Selection 2005 18: 1-10; doi:10.1093/protein/gzh102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ozlem Keskin and Ruth Nussinov

Favorable scaffolds: proteins with different sequence, structure and function may associate in similar ways
PEDS Advance Access published on February 24, 2005
Protein Engineering, Design and Selection 2005 18: 11-24; doi:10.1093/protein/gzh095 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Shulga-Morskoy and B.E. Rich

Bioactive IL7-diphtheria fusion toxin secreted by mammalian cells
PEDS Advance Access published on March 14, 2005
Protein Engineering, Design and Selection 2005 18: 25-31; doi:10.1093/protein/gzi007 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Johannes Müllegger, Michael Jahn, Hong-Ming Chen, R.Antony J. Warren, and Stephen G. Withers

Engineering of a thioglycoligase: randomized mutagenesis of the acid–base residue leads to the identification of improved catalysts
PEDS Advance Access published on March 14, 2005
Protein Engineering, Design and Selection 2005 18: 33-40; doi:10.1093/protein/gzi003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susanne Cranz-Mileva, Claire T. Friel, and Sheena E. Radford

Helix stability and hydrophobicity in the folding mechanism of the bacterial immunity protein Im9
PEDS Advance Access published on March 15, 2005
Protein Engineering, Design and Selection 2005 18: 41-50; doi:10.1093/protein/gzi002 [Abstract] [FREE Full Text] [PDF] [Supplementary data][Supplementary data] [Request Permissions]  

C. Roodveldt and D.S. Tawfik

Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state
PEDS Advance Access published on March 15, 2005
Protein Engineering, Design and Selection 2005 18: 51-58; doi:10.1093/protein/gzi005 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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