Cover illustration A new approach is reported to enhance the cell-permeability of a protein. Specifically, a patch of arginine residues is installed so as to enhance Coulombic interactions with the cell surface and hence increase cellular internalization, without affecting other properties of the protein. Here, “arginine grafting” is shown to enhance the toxicity of RNase A for human erythroleukemia cells. The image depicts electrostatic potential maps of wild-type RNase A and a model of its E49R/D53R variant (blue = cationic; red = anionic). For further details, please see Fuchs et al. pp. 505-510
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