Cover illustration The cellulose surface induced rearrangement of the carbohydrate-binding module (CBM) of Trichoderma reesei cellobiohydrolase I during a molecular dynamics simulation using CHARMM. Three exposed tyrosine residues (grey) of the CBM create a ‘hydrophobic face’ which binds the CBM to the cellulose surface. During this simulation, a fourth tyrosine residue (red) normally sequestered within the CBM was observed moving to a new position adjacent to the broken strand on the cellulose surface, suggesting an induced fit binding mechanism. Cover illustration by Ross C.Walker and Amit Chourasia of San Diego Supercomputer Center. For further details please see Nimlos et al. pp. 179-187.
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