Protein Engineering Design and Selection

Editorial

Andrew Bradbury

Message from the Editors
Protein Engineering, Design and Selection 2009 22: 111; doi:10.1093/protein/gzn082 [Extract] [Full Text] [PDF] [Request Permissions]  

Original articles

Get checked abstract Michael J. Sweredoski and Pierre Baldi

COBEpro: a novel system for predicting continuous B-cell epitopes
PEDS Advance Access published on December 10, 2008
Protein Engineering, Design and Selection 2009 22: 113-120; doi:10.1093/protein/gzn075 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Annemarie Honegger, Alain Daniel Malebranche, Daniela Röthlisberger, and Andreas Plückthun

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains
PEDS Advance Access published on January 10, 2009
Protein Engineering, Design and Selection 2009 22: 121-134; doi:10.1093/protein/gzn077 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Markus Kügler, Christoph Stein, Michael Schwenkert, Domenica Saul, Lena Vockentanz, Thomas Huber, Svava K. Wetzel, Oliver Scholz, Andreas Plückthun, Annemarie Honegger, and Georg H. Fey

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework
PEDS Advance Access published on February 1, 2009
Protein Engineering, Design and Selection 2009 22: 135-147; doi:10.1093/protein/gzn079 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Paola Secco, Elena D'Agostini, Roberto Marzari, Marta Licciulli, Roberto Di Niro, Sara D'Angelo, Andrew R.M. Bradbury, Umberto Dianzani, Claudio Santoro, and Daniele Sblattero

Antibody library selection by the β-lactamase protein fragment complementation assay
PEDS Advance Access published on September 30, 2008
Protein Engineering, Design and Selection 2009 22: 149-158; doi:10.1093/protein/gzn053 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract C. Lloyd, D. Lowe, B. Edwards, F. Welsh, T. Dilks, C. Hardman, and T. Vaughan

Modelling the human immune response: performance of a 10¹¹ human antibody repertoire against a broad panel of therapeutically relevant antigens
PEDS Advance Access published on October 29, 2008
Protein Engineering, Design and Selection 2009 22: 159-168; doi:10.1093/protein/gzn058 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Kathrin Zuberbühler, Alessandro Palumbo, Camilla Bacci, Leonardo Giovannoni, Roberto Sommavilla, Manuela Kaspar, Eveline Trachsel, and Dario Neri

A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells
PEDS Advance Access published on November 20, 2008
Protein Engineering, Design and Selection 2009 22: 169-174; doi:10.1093/protein/gzn068 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Martin Schlapschy, Marton Fogarasi, Helga Gruber, Oliver Gresch, Claudia Schäfer, Yasmine Aguib, and Arne Skerra

Functional humanization of an anti-CD16 Fab fragment: obstacles of switching from murine to human or light chains
PEDS Advance Access published on November 19, 2008
Protein Engineering, Design and Selection 2009 22: 175-188; doi:10.1093/protein/gzn066 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract J. Gabbard, N. Velappan, R. Di Niro, J. Schmidt, C.A. Jones, S.M. Tompkins, and A.R.M. Bradbury

A humanized anti-M2 scFv shows protective in vitro activity against influenza
PEDS Advance Access published on December 2, 2008
Protein Engineering, Design and Selection 2009 22: 189-198; doi:10.1093/protein/gzn070 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Remy Robert, Olan Dolezal, Lynne Waddington, Meghan K. Hattarki, Roberto Cappai, Colin L. Masters, Peter J. Hudson, and Kim L. Wark

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers
PEDS Advance Access published on October 16, 2008
Protein Engineering, Design and Selection 2009 22: 199-208; doi:10.1093/protein/gzn052 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jeffrey V. Leyton, Tove Olafsen, Mark A. Sherman, Karl B. Bauer, Patrick Aghajanian, Robert E. Reiter, and Anna M. Wu

Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors
PEDS Advance Access published on October 28, 2008
Protein Engineering, Design and Selection 2009 22: 209-216; doi:10.1093/protein/gzn055 [Abstract] [Full Text] [PDF] [Request Permissions]  

Short communications

Get checked abstract Kip Dudgeon, Kristoffer Famm, and Daniel Christ

Sequence determinants of protein aggregation in human VH domains
PEDS Advance Access published on October 28, 2008
Protein Engineering, Design and Selection 2009 22: 217-220; doi:10.1093/protein/gzn059 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. Yong, B. Tolner, S. Nagl, R.B. Pedley, K. Chester, A.J. Green, A. Mayer, S. Sharma, and R. Begent

Data standards for minimum information collection for antibody therapy experiments
Protein Engineering, Design and Selection 2009 22: 221-224; doi:10.1093/protein/gzp003 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

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