Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Alan R. Fersht and Tim N.C. Wells

Linear free energy relationships in enzyme binding interactions studied by protein engineering
Protein Eng. 1991 4: 229-231; doi:10.1093/protein/4.3.229 [Abstract] [PDF] [Request Permissions]  

Shuichi Hirono and Peter A. Kollman

Relative binding free energy calculations of inhibitors to two mutants (Glu46— Ala/Gln) of ribonuclease T1 using molecular dynamics/free energy perturbation approaches
Protein Eng. 1991 4: 233-243; doi:10.1093/protein/4.3.233 [Abstract] [PDF] [Request Permissions]  

A.V. Efimov

Structure of --hairpins with short connections
Protein Eng. 1991 4: 245-250; doi:10.1093/protein/4.3.245 [Abstract] [PDF] [Request Permissions]  

Juswinder Singh, José Saldanha, and Janet M. Thornton

A novel method for the modelling of peptide ligands to their receptors
Protein Eng. 1991 4: 251-261; doi:10.1093/protein/4.3.251 [Abstract] [PDF] [Request Permissions]  

Angela M. Gronenborn and G.Marius Clore

Modeling the three–dimensional structure of the monocyte chemo–attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8
Protein Eng. 1991 4: 263-269; doi:10.1093/protein/4.3.263 [Abstract] [PDF] [Request Permissions]  

Markéta J.J.M. Zvelebil, C.Roland Wolf, and Michael J.E. Sternberg

A predicted three-dimensional structure of human cytochrome P450: implications for substrate specificity
Protein Eng. 1991 4: 271-282; doi:10.1093/protein/4.3.271 [Abstract] [PDF] [Request Permissions]  

H.Tonie Wright

Sequence and structure determinants of the nonenzymatic deamidation of asparagine and glutamine residues in proteins
Protein Eng. 1991 4: 283-294; doi:10.1093/protein/4.3.283 [Abstract] [PDF] [Request Permissions]  

Stuart R. Stone and Jan Hofsteenge

Recombinant hirudin: kinetic mechanism for the inhibition of human thrombin
Protein Eng. 1991 4: 295-300; doi:10.1093/protein/4.3.295 [Abstract] [PDF] [Request Permissions]  

Sung-Sup Suh, Barry L. Haymore, and Frances H. Arnold

Characterization of His-X₃-His sites in -helices of synthetic metal-binding bovine somatotropin
Protein Eng. 1991 4: 301-305; doi:10.1093/protein/4.3.301 [Abstract] [PDF] [Request Permissions]  

Robert Mé, Céline Plouffe, Henry E. Khouri, Robert Dupras, Daniel C. Tessier, Thierry Vernet, David Y. Thomas, and Andrew C. Storer

Removal of an inter-domain hydrogen bond through site-directed mutagenesis: role of serine 176 in the mechanism of papain
Protein Eng. 1991 4: 307-311; doi:10.1093/protein/4.3.307 [Abstract] [PDF] [Request Permissions]  

A. J. Wolfson, M. Kanaoka, F. T. K. Lau, and D. Ringe

Insertion of an elastase-binding loop into interleukin-1ß
Protein Eng. 1991 4: 313-317; doi:10.1093/protein/4.3.313 [Abstract] [PDF] [Request Permissions]  

P.A. Handford, P.R. Winship, and G.G. Brownlee

Protein engineering of the propeptide of human factor IX
Protein Eng. 1991 4: 319-323; doi:10.1093/protein/4.3.319 [Abstract] [PDF] [Request Permissions]  

Béatrice Py, Bortoli-German Isabelle, Jacques Haiech, Marc Chippaux, and Frédéric Barras

Cellulase EGZ of Erwinia chrysanthemi: structural organization and importance of His98 and Glu133 residues for catalysis
Protein Eng. 1991 4: 325-333; doi:10.1093/protein/4.3.325 [Abstract] [PDF] [Request Permissions]  

Daniel Lundell, Charles Lunn, David Dalgarno, James Fossetta, Robert Greenberg, Richard Reim, Michael Grace, and Satwant Narula

The carboxyl-terminal region of human interferon is important for biological activity: mutagenic and NMR analysis
Protein Eng. 1991 4: 335-341; doi:10.1093/protein/4.3.335 [Abstract] [PDF] [Request Permissions]  

B.Göran Karlsson, Margareta Nordling, Torbjörn Pascher, Li-Chu Tsai, Lennart Sjölin, and Lennart G. Lundberg

Cassette mutagenesis of Met121 in azurin from Pseudomonas aeruginosa
Protein Eng. 1991 4: 343-349; doi:10.1093/protein/4.3.343 [Abstract] [PDF] [Request Permissions]  

Michelle F. Browner, Peter Rasor, Stuart Tugendreich, and Robert J. Fletterick

Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli
Protein Eng. 1991 4: 351-357; doi:10.1093/protein/4.3.351 [Abstract] [PDF] [Request Permissions]  

Corrigendum:

Thomas Niermann and Kasper Kirschner

Improving the prediction of secondary structure of ‘TIM-barrel’ enzymes
Protein Eng. 1991 4: 359-370; doi:10.1093/protein/4.3.359 [Abstract] [PDF] [Request Permissions]  

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