Protein Engineering Design and Selection

COMMENTARY:

Ronald Wetzel

Learning from the immune system: laboratory methods for creating and refining molecular diversity in polypeptides
Protein Eng. 1991 4: 371-374; doi:10.1093/protein/4.4.371 [PDF] [Request Permissions]  

REVIEW:

Patrick Argos, Martin Vingron, and Gerhard Vogt

Protein sequence comparison: methods and significance
Protein Eng. 1991 4: 375-383; doi:10.1093/protein/4.4.375 [PDF] [Request Permissions]  

RESEARCH REVIEW:

Cynthia R. Goh and Alan G. Porter

Structural and functional domains in human tumour necrosis factors
Protein Eng. 1991 4: 385-389; doi:10.1093/protein/4.4.385 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Raymond C. Stevens, Yuh Min Chook, Charles Y. Cho, William N. Lipscomb, and Evan R. Kantrowitz

Escherichia coli aspartate carbamoyltransferase: the probing of crystal structure analysis via site-specific mutagenesis
Protein Eng. 1991 4: 391-408; doi:10.1093/protein/4.4.391 [Abstract] [PDF] [Request Permissions]  

Keith Rose, Reto Stöcklin, Luc-Alain Savoy, Pierre-Olivier Regamey, Robin E. Offord, Pierre Vuagnat, and Jan Markussen

Reaction mechanism of trypsin-catalysed semisynthesis of human insulin studied by fast atom bombardment mass spectrometry
Protein Eng. 1991 4: 409-412; doi:10.1093/protein/4.4.409 [Abstract] [PDF] [Request Permissions]  

Kazuo Sumi, Takaaki Nishioka, and Jun'ichi Oda

Similarity graphing and enzyme-reaction database: methods to detect sequence regions of importance for recognition of chemical structures
Protein Eng. 1991 4: 413-420; doi:10.1093/protein/4.4.413 [Abstract] [PDF] [Request Permissions]  

A.D. Factor and E.L. Mehler

Graphical representation of hydrogen bonding patterns in proteins
Protein Eng. 1991 4: 421-425; doi:10.1093/protein/4.4.421 [Abstract] [PDF] [Request Permissions]  

Raymond P. Oomen, N.Martin Young, and David R. Bundle

Molecular modeling of antibody–antigen complexes between the Brucella abortus O-chain polysaccharide and a specific monoclonal antibody
Protein Eng. 1991 4: 427-433; doi:10.1093/protein/4.4.427 [Abstract] [PDF] [Request Permissions]  

Thy-Hou Lin and Duane P. Grandgenett

Retrovirus integrase: identification of a potential leucine zipper motif
Protein Eng. 1991 4: 435-441; doi:10.1093/protein/4.4.435 [Abstract] [PDF] [Request Permissions]  

T. Fujiyoshi-Yoneda, S. Yoneda, K. Kitamura, T. Amisaki, K. Ikeda, M. Inoue, and T. Ishida

Adaptability of restrained molecular dynamics for tertiary structure prediction: application to Crotalus atrox venom phospholipase A₂
Protein Eng. 1991 4: 443-450; doi:10.1093/protein/4.4.443 [Abstract] [PDF] [Request Permissions]  

Mark R. Hurle, Stephen Anderson, and Irwin D. Kuntz

Confirmation of the predicted source of a slow folding reaction: proline 8 of bovine pancreatic trypsin inhibitor
Protein Eng. 1991 4: 451-455; doi:10.1093/protein/4.4.451 [Abstract] [PDF] [Request Permissions]  

Arnaud Blondel and Hugues Bedouelle

Engineering the quaternary structure of an exported protein with a leucine zipper
Protein Eng. 1991 4: 457-461; doi:10.1093/protein/4.4.457 [Abstract] [PDF] [Request Permissions]  

Tetsuyuki Kiyokawa, Diane P. Williams, Catherine E. Snider, Terry B. Strom, and John R. Murphy

Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells
Protein Eng. 1991 4: 463-468; doi:10.1093/protein/4.4.463 [Abstract] [PDF] [Request Permissions]  

U. Finkeldei, H. R. Kalbitzer, R. Eisermann, G. C. Stewart, and W. Hengstenberg

Enzyme III^lac of the staphylococcal phosphoenolpyruvate-dependent phosphotransferase system: site-specific mutagenesis of histidine residues, biochemical characterization and ¹H-NMR studies
Protein Eng. 1991 4: 469-473; doi:10.1093/protein/4.4.469 [Abstract] [PDF] [Request Permissions]  

U. Finkeldei and W. Hengstenberg

Staphylococcal lactose phosphoenolpyruvate-dependent phosphotransferase system: site-specific mutagenesis on the lacE gene gives evidence that a cysteine residue is responsible for phosphorylation
Protein Eng. 1991 4: 475-478; doi:10.1093/protein/4.4.475 [Abstract] [PDF] [Request Permissions]  

Pieter Vos, Ingrid J. Boerrigter, Girbe Buist, Alfred J. Haandrikman, Monique Nijhuis, Marjon B. de Reuver, Roland J. Siezen, Gerard Venema, Willem M. de Vos, and Jan Kok

Engineering of the Lactococcus lactis serine proteinase by construction of hybrid enzymes
Protein Eng. 1991 4: 479-484; doi:10.1093/protein/4.4.479 [Abstract] [PDF] [Request Permissions]  

Laurent Jespers, Etienne Sonveaux, Jacques Fastrez, Angela Phanapoulos, and John Davison

Overexpression of the phage lambda lysozyme cloned in Escherichia coli: use of a degenerative mixture of synthetic ribosome binding sites and increase of the protein stability in vivo
Protein Eng. 1991 4: 485-492; doi:10.1093/protein/4.4.485 [Abstract] [PDF] [Request Permissions]  

Dean W. Hum and Robert E. Mackenzie

Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli
Protein Eng. 1991 4: 493-500; doi:10.1093/protein/4.4.493 [Abstract] [PDF] [Request Permissions]  

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