Protein Engineering Design and Selection

COMMENTARY:

Robin Offord

Going beyond the code
Protein Eng. 1991 4: 709-710; doi:10.1093/protein/4.7.709 [PDF] [Request Permissions]  

REVIEW:

T.J.P Hubbard and C. Sander

The role of heat-shock and chaperone proteins in protein folding: possible molecular mechanisms
Protein Eng. 1991 4: 711-717; doi:10.1093/protein/4.7.711 [Abstract] [PDF] [Request Permissions]  

RESEARCH REVIEW:

Roland J. Siezen, William M. de Vos, Jack A.M. Leunissen, and Bauke W. Dijkstra

Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases
Protein Eng. 1991 4: 719-737; doi:10.1093/protein/4.7.719 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

S.J. Prestrelski and T. Arakawa

The solution structure and conformational dynamics of tumor necrosis factor- and a (Cys69 – Asp; Cys101 – Arg) analog as examined by IR spectroscopy and hydrogen exchange
Protein Eng. 1991 4: 739-743; doi:10.1093/protein/4.7.739 [Abstract] [PDF] [Request Permissions]  

Marc Beauregard, Karine Goraj, Vincent Goffin, Karel Heremans, Eric Goormaghtigh, Jean-Marie Ruysschaert, and Joseph A. Martial

Spectroscopic investigation of structure in octarellin (a de novo protein designed to adopt the /ß-barred packing)
Protein Eng. 1991 4: 745-749; doi:10.1093/protein/4.7.745 [Abstract] [PDF] [Request Permissions]  

Dominic A. Clark, Jack Shirazi, and Christopher J. Rawlings

Protein topology prediction through constraint–based search and the evaluation of topological folding rules
Protein Eng. 1991 4: 751-760; doi:10.1093/protein/4.7.751 [Abstract] [PDF] [Request Permissions]  

R.H. Yun and Jan Hermans

Conformation equilibria of valine studies by dynamics simulation
Protein Eng. 1991 4: 761-766; doi:10.1093/protein/4.7.761 [Abstract] [PDF] [Request Permissions]  

J. Grötzinger, M. Engels, E. Jacoby, A. Wollme, and W. Straßburger

A model for the C5a receptor and for T its interaction with the ligand
Protein Eng. 1991 4: 767-771; doi:10.1093/protein/4.7.767 [Abstract] [PDF] [Request Permissions]  

Catherine A. Kettleborough, José Saldanha, Victoria J. Heath, Charlotte J. Morrison, and Mary M. Bendig

Humanization of a mouse monoclonal antibody by CDR–grafting: the importance of framework residues on loop conformation
Protein Eng. 1991 4: 773-783; doi:10.1093/protein/4.7.773 [Abstract] [PDF] [Request Permissions]  

Cynthia R. Goth, Chong-Seng Loh, and Alan G. Porter

Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin)
Protein Eng. 1991 4: 785-791; doi:10.1093/protein/4.7.785 [Abstract] [PDF] [Request Permissions]  

Toshio Hakoshima, Masahiro Tanaka, Takeshi Itoh, Ken-khi Tomita, Takashi Amisaki, Satoshi Nishikawa, Hiroshi Morioka, Sei-ichi Uesugi, Eiko Ohtsuka, and Morio Ikehara

Hydrophobic effects on protein/nucleic acid interaction: enhancement of substrate binding by mutating tyrosine 45 to tryptophan in ribonuclease Tl
Protein Eng. 1991 4: 793-799; doi:10.1093/protein/4.7.793 [Abstract] [PDF] [Request Permissions]  

Wlodek Mandecki, Mary Ann Shallcross, Janusz Sowadski, and Susan Tomazic-Allen

Mutagenesis of conserved residues within the active site of Escherichia coli alkaline phosphatase yields enzymes with increased k_cat
Protein Eng. 1991 4: 801-804; doi:10.1093/protein/4.7.801 [Abstract] [PDF] [Request Permissions]  

Myriam Delaire, Francoise Lenfant, Roger Labia, and Jean-Michel Masson

Site-directed mutagenesis on TEM-1 ß-lactamase: role of Glul66 in catalysis and substrate binding
Protein Eng. 1991 4: 805-810; doi:10.1093/protein/4.7.805 [Abstract] [PDF] [Request Permissions]  

Francoise Jacob-Dubuisson, Josette Lamotte-Brasseur, Otto Dideberg, Bernard Joris, and Jean-Marie Frére

Arginine 220 is a critical residue for the catalytic mechanism of the Streptomyces albus G ß-lactamase
Protein Eng. 1991 4: 811-819; doi:10.1093/protein/4.7.811 [Abstract] [PDF] [Request Permissions]  

Meltsje de Hoop, Sigridur Asgeirsdottir, Mieke Blaauw, Marten Veenhuis, Jim Cregg, Martin Gleeson, and Geert AB

Mutations in the FAD-binding fold of alcohol oxidase from Hansenula polymorpha
Protein Eng. 1991 4: 821-829; doi:10.1093/protein/4.7.821 [Abstract] [PDF] [Request Permissions]  

Rudolf K. Allemann, Scott R. Presnell, and Steven A. Benner

A hybrid of bovine pancreatic ribonuclease and human angiogenin: an external loop as a module controlling substrate specificity?
Protein Eng. 1991 4: 831-835; doi:10.1093/protein/4.7.831 [Abstract] [PDF] [Request Permissions]  

Kristiina Takkinen, Marja-Leena Laukkanen, Dorothea Sizmann, Kaija Alfthan, Tiina Immonen, Liisa Vanne, Matti Kaartinen, Jonathan K.C. Knowles, and Tuula T. Teeri

An active single-chain antibody containing a cellulase linker domain is secreted by Escherichia coli
Protein Eng. 1991 4: 837-841; doi:10.1093/protein/4.7.837 [Abstract] [PDF] [Request Permissions]  

Christine Cagnon, Viviane Valverde, and Jean-Michel Masson

A new family of sugar-inducible expression vectors for Escherichia coli
Protein Eng. 1991 4: 843-847; doi:10.1093/protein/4.7.843 [Abstract] [PDF] [Request Permissions]  

Letters to the Editor:

C.D. Paliakasis and M. Kokkinidis

The stability of the four--helix bundle motif in proteins
Protein Eng. 1991 4: 849; doi:10.1093/protein/4.7.849 [PDF] [Request Permissions]  

K.-C. Chou

Reply from K.-C.Chou: The role of loops in stabilizing bundle motif protein structures
Protein Eng. 1991 4: 849-850; doi:10.1093/protein/4.7.849-a [PDF] [Request Permissions]  

Corrigendum:

K. Darwish, H. Li, and T.L. Poulos

Engineering proteins, subcloning and hyperexpressing xidoreductase genes
Protein Eng. 1991 4: 850; doi:10.1093/protein/4.7.850 [PDF] [Request Permissions]  

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