Protein Engineering Design and Selection

Letter from the Editors:

Letter from the Editors
Protein Eng. 1992 5: 189; doi:10.1093/protein/5.3.189 [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Gerald Böhm, Rudolf Muhr, and Rainer Jaenicke

Quantitative analysis of protein far UV circular dichroism spectra by neural networks
Protein Eng. 1992 5: 191-195; doi:10.1093/protein/5.3.191 [Abstract] [PDF] [Request Permissions]  

David L. Ollis, Eong Cheah, Miroslaw Cygler, Bauke Dijkstra, Felix Frolow, Sybille M. Franken, Michal Harel, S. Jamse Remington, Israel Silman, Joseph Schrag, Joel L. Sussman, Koen H.G. Verschueren, and Adrian Goldman

The /ß hydrolase fold
Protein Eng. 1992 5: 197-211; doi:10.1093/protein/5.3.197 [Abstract] [PDF] [Request Permissions]  

M. Schiffer, C.-H. Chang, and F.J. Stevens

The function of tryptophan residues in membrane proteins
Protein Eng. 1992 5: 213-214; doi:10.1093/protein/5.3.213 [Abstract] [PDF] [Request Permissions]  

Frederick S. Lee, Zhen-Tao Chu, Michael B. Bolger, and Arieh Warshel

Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603
Protein Eng. 1992 5: 215-228; doi:10.1093/protein/5.3.215 [Abstract] [PDF] [Request Permissions]  

Thomas Simon and Klaus Rajewsky

A functional antibody mutant with an insertion in the framework region 3 loop of the V_H domain: implications for antibody engineering
Protein Eng. 1992 5: 229-234; doi:10.1093/protein/5.3.229 [Abstract] [PDF] [Request Permissions]  

Andrew C. Jamieson and Carl A. Batt

Fluorescent properties of the Escherichia coli D-xylose isomerase active site
Protein Eng. 1992 5: 235-240; doi:10.1093/protein/5.3.235 [Abstract] [PDF] [Request Permissions]  

Fadi Lakkis, Bryan Landgraf, Zilong Wen, Terry B. Strom, and John R. Murphy

Phe496 and Leu497 are essential for receptor binding and cytotoxic action of the murine interleukin-4 receptor targeted fusion toxin DAB₃₈₉-mIL-4
Protein Eng. 1992 5: 241-248; doi:10.1093/protein/5.3.241 [Abstract] [PDF] [Request Permissions]  

C.A. Lunn, J. Fossetta, N. Murgolo, P. J. Zavodny, D. Lundell, and S.K. Narula

A point mutation that decreases the thermal stability of human interferon
Protein Eng. 1992 5: 249-252; doi:10.1093/protein/5.3.249 [Abstract] [PDF] [Request Permissions]  

C.A. Lunn, J. Fossetta, D. Dalgarno, N. Murgolo, W. Windsor, P. J. Zavodny, S.K. Narula, and D. Lundell

A point mutation of human interferon abolishes receptor recognition
Protein Eng. 1992 5: 253-257; doi:10.1093/protein/5.3.253 [Abstract] [PDF] [Request Permissions]  

Nicholas F. Paoni, Canio J. Refino, Kevin Brady, Luis C. Pena, Hung V. Nguyen, Elizabeth M. Kerr, Adriana C. Johnson, Florian M. Wurm, Robert van Reis, David Botstein, and William F. Bennett

Involvement of residues 296–299 in the enzymatic activity of tissue-type plasminogen activator
Protein Eng. 1992 5: 259-266; doi:10.1093/protein/5.3.259 [Abstract] [PDF] [Request Permissions]  

Ellen Witt, George C. Stewart, and Wolfgang Hengstenberg

A new protein conjugate that replaces the use of secondary antibodies engineered from the two staphylococcal enzymes protein A and 6-phospho-ß-galactosidase
Protein Eng. 1992 5: 267-271; doi:10.1093/protein/5.3.267 [Abstract] [PDF] [Request Permissions]  

Daniel Gillet, Frédéric Ducancel, Elisabeth Pradel, Michel Léonetti, André Ménez, and Jean-Claude Boulain

Insertion of a disulfide-containing neurotoxin into E.coil alkaline phosphatase: the hybrid retains both biological activities
Protein Eng. 1992 5: 273-278; doi:10.1093/protein/5.3.273 [Abstract] [PDF] [Request Permissions]  

Susan K. Hinchman and Sheldon M. Schuster

Overproduction, preparation of monoclonal antibodies and purification of E.coli asparagine synthetase A
Protein Eng. 1992 5: 279-283; doi:10.1093/protein/5.3.279 [Abstract] [PDF] [Request Permissions]  

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