Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Robert M. Cooke, Brian G. Carter, Peter Murray-Rust, Michael J. Hartshorn, Pawel Herzyk, and Roderick E. Hubbard

The solution structure of echistatin: evidence for disulphide bond rearrangement in homologous snake toxins
Protein Eng. 1992 5: 473-477; doi:10.1093/protein/5.6.473 [Abstract] [PDF] [Request Permissions]  

Atsushi Ogiwara, Ikuo Uchiyama, Yasuhiko Seto, and Minoru Kanehisa

Construction of a dictionary of sequence motifs that characterize groups of related proteins
Protein Eng. 1992 5: 479-488; doi:10.1093/protein/5.6.479 [Abstract] [PDF] [Request Permissions]  

Mark Mayhew, Penny Handford, Martin Baron, Albert G. D. Tse, Iain D. Campbell, and George G. Brownlee

Ligand requirements for Ca²⁺ binding to EGF-like domains
Protein Eng. 1992 5: 489-494; doi:10.1093/protein/5.6.489 [Abstract] [PDF] [Request Permissions]  

Takashi Nakazawa, Hikaru Kawai, Yuko Okamoto, and Masataka Fukugita

ß-sheet folding of fragment (16–36) of bovine pancreatic trypsin inhibitor as predicted by Monte Carlo simulated annealing
Protein Eng. 1992 5: 495-503; doi:10.1093/protein/5.6.495 [Abstract] [PDF] [Request Permissions]  

Carolyn J. Terry and Colin C. F. Blake

Comparison of the modelled thyroxine binding site in TBG with the experimentally determined site in transthyretin
Protein Eng. 1992 5: 505-510; doi:10.1093/protein/5.6.505 [Abstract] [PDF] [Request Permissions]  

Barbara K. Klein, Joseph O. Polazzi, Catherine S. Devine, Shaukat H. Rangwala, and Peter O. Olins

Effects of signal peptide changes on the secretion of bovine somatotropin (bST) from Escherichia coli
Protein Eng. 1992 5: 511-517; doi:10.1093/protein/5.6.511 [Abstract] [PDF] [Request Permissions]  

David N. Brems, Patricia L. Brown, Christopher Bryant, Ronald E. Chance, L. Kenney Green, Harlan B. Long, Alita A. Miller, Rohn Millican, James E. Shields, and Bruce H. Frank

Improved insulin stability through amino acid substitution
Protein Eng. 1992 5: 519-525; doi:10.1093/protein/5.6.519 [Abstract] [PDF] [Request Permissions]  

David N. Brems, Leila A. Alter, Michael J. Beckage, Ronald E. Chance, Richard D. DiMarchi, L. Kenney Green, Harlan B. Long, Allen H. Pekar, James E. Shields, and Bruce H. Frank

Altering the association properties of insulin by amino acid replacement
Protein Eng. 1992 5: 527-533; doi:10.1093/protein/5.6.527 [Abstract] [PDF] [Request Permissions]  

S.L. Turner, G.C. Ford, A. Mountain, and A. Moir

Selection of a thermostable variant of chloramphenicol acetyltransferase (Cat-86)
Protein Eng. 1992 5: 535-541; doi:10.1093/protein/5.6.535 [Abstract] [PDF] [Request Permissions]  

Immaculada Margarit, Susanna Camagnoli, Francesco Frigerio, Guido Grandi, Vincenzo De Filippis, and Angelo Fontana

Cumulative stabilizing effects of glycine to alanine substitutions in Bacillus subtilis neutral protease
Protein Eng. 1992 5: 543-550; doi:10.1093/protein/5.6.543 [Abstract] [PDF] [Request Permissions]  

Mikael Widersten and Bengt Mannervik

A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes
Protein Eng. 1992 5: 551-557; doi:10.1093/protein/5.6.551 [Abstract] [PDF] [Request Permissions]  

Dennis N. Luck, Peter W. Gout, E. Rand Sutherland, Kelly Fox, Marianne Huyer, and Michael Smith

Analysis of disuiphide bridge function in recombinant bovine prolactin using site-specific mutagenesis and renaturation under mild alkaline conditions: a crucial role for the central disuiphide bridge in the mitogenic activity of the hormone
Protein Eng. 1992 5: 559-567; doi:10.1093/protein/5.6.559 [Abstract] [PDF] [Request Permissions]  

Jing Wang, Julie Chao, and Lee Chao

Specificity determinants of rat tissue kallikrein probed by site-directed mutagenesis
Protein Eng. 1992 5: 569-575; doi:10.1093/protein/5.6.569 [Abstract] [PDF] [Request Permissions]  

Michael G. Gore, William F. Ferris, Andrew G. Popplewell, Michael Scawen, and Tony Atkinson

pH-sensitive interactions between IgG and a mutated IgG-binding protein based upon two B domains of Protein A from Staphylococcus aureus
Protein Eng. 1992 5: 577-582; doi:10.1093/protein/5.6.577 [Abstract] [PDF] [Request Permissions]  

Fernando Rock, Margaret Everett, and Michel Klein

Overexpression and structure-function analysis of a bioengineered IL-2/IL-6 chimeric lymphokine
Protein Eng. 1992 5: 583-591; doi:10.1093/protein/5.6.583 [Abstract] [PDF] [Request Permissions]  

PROTOCOL:

Bernhard Fischer, Barry Perry, Ian Sumner, and Peter Goodenough

A novel sequential procedure to enhance the renaturation of recombinant protein from Escherichia coil inclusion bodies
Protein Eng. 1992 5: 593-596; doi:10.1093/protein/5.6.593 [PDF] [Request Permissions]  

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