Protein Engineering Design and Selection

REVIEW:

Keith Brocklehurst

A sound basis for pH-dependent kinetic studies on enzymes
Protein Eng. 1994 7: 291-299; doi:10.1093/protein/7.3.291 [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Dirk W. Heinz and Brian W. Matthews

Rapid crystallization of T4 lysozyme by intermolecular disulfide cross-linking
Protein Eng. 1994 7: 301-307; doi:10.1093/protein/7.3.301 [Abstract] [PDF] [Request Permissions]  

Alia Gustchina, Clare Sansom, Martine Prevost, Jean Richelle, Shoshana Y. Wodak, Alexander Wlodawer, and Irene T. Weber

Energy calculations and analysis of HIV-1 protease-inhibitor crystal structures
Protein Eng. 1994 7: 309-316; doi:10.1093/protein/7.3.309 [Abstract] [PDF] [Request Permissions]  

Boryeu Mao, Kuo-Chen Chou, and Chun-Ting Zhang

Protein folding classes: a geometric interpretation of the amino acid composition of globular proteins
Protein Eng. 1994 7: 319-330; doi:10.1093/protein/7.3.319 [Abstract] [PDF] [Request Permissions]  

Mihaly Mezei

A heuristic procedure for the detection of locally similar substructures of two equivalent structures
Protein Eng. 1994 7: 331-333; doi:10.1093/protein/7.3.331 [Abstract] [PDF] [Request Permissions]  

Micheal H. Zehfus

Binary discontinuous compact protein domains
Protein Eng. 1994 7: 335-340; doi:10.1093/protein/7.3.335 [Abstract] [PDF] [Request Permissions]  

William R. Taylor and Kerr Hatrick

Compensating changes in protein multiple sequence alignments
Protein Eng. 1994 7: 341-348; doi:10.1093/protein/7.3.341 [Abstract] [PDF] [Request Permissions]  

I.N. Shindyalov, N.A. Kolchanov, and C. Sander

Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations?
Protein Eng. 1994 7: 349-358; doi:10.1093/protein/7.3.349 [Abstract] [PDF] [Request Permissions]  

Robert W. Harrison, Igor V. Kourinov, and Lawrence C. Andrews

The Fourier-Green's function and the rapid evaluation of molecular potentials
Protein Eng. 1994 7: 359-369; doi:10.1093/protein/7.3.359 [Abstract] [PDF] [Request Permissions]  

Richard M. Jackson and Michael J.E. Sternberg

Application of scaled particle theory to model the hydrophobic effect: implications for molecular association and protein stability
Protein Eng. 1994 7: 371-383; doi:10.1093/protein/7.3.371 [Abstract] [PDF] [Request Permissions]  

Johan Åqvist, Carmen Medina, and Jan-Erik Samuelsson

A new method for predicting binding affinity in computer-aided drug design
Protein Eng. 1994 7: 385-391; doi:10.1093/protein/7.3.385 [Abstract] [PDF] [Request Permissions]  

Pedro M. Coutinho and Peter J. Reilly

Structure–function relationships in the catalytic and starch binding domains of glucoamylase
Protein Eng. 1994 7: 393-400; doi:10.1093/protein/7.3.393 [Abstract] [PDF] [Request Permissions]  

Kentaro Miyazaki and Tairo Oshima

Co-enzyme specificity of 3-isopropylmalate dehydrogenase from Thermits thermophilus HB8
Protein Eng. 1994 7: 401-403; doi:10.1093/protein/7.3.401 [Abstract] [PDF] [Request Permissions]  

Steven C. Almo, Douglas L. Smith, Avis T. Danishefsky, and Dagmar Ringe

The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E.coli
Protein Eng. 1994 7: 405-412; doi:10.1093/protein/7.3.405 [Abstract] [PDF] [Request Permissions]  

James J. Onuffer and Jack F. Kirsch

Characterization of the apparent negative co-operativity induced in Escherichia coli aspartate aminotransferase by the replacement of Asp222 with alanine. Evidence for an extremely slow conformational change
Protein Eng. 1994 7: 413-424; doi:10.1093/protein/7.3.413 [Abstract] [PDF] [Request Permissions]  

Florence Hardy, Gerrit Vriend, Bernard van der Vinne, Francesco Frigerio, Guido Grandi, Gerard Venema, and Vincent G.H. Ejjsink

The effect of engineering surface loops on the thermal stability of Bacillus subtilis neutral protease
Protein Eng. 1994 7: 425-430; doi:10.1093/protein/7.3.425 [Abstract] [PDF] [Request Permissions]  

Dan S. Tawfik, Rachel Chap, Zelig Eshhar, and Bernard S. Green

pH on–off switching of antibody-hapten binding by site-specific chemical modification of tyrosine
Protein Eng. 1994 7: 431-434; doi:10.1093/protein/7.3.431 [Abstract] [PDF] [Request Permissions]  

Tomoyuki Nakatani, Yu-Chun Lone, Junko Yamakawa, Masaharu Kanaoka, Hideyuki Gomi, John Wydenes, and Hiroshi Noguchi

Humanization of mouse anti-human IL-2 receptor antibody B-B10
Protein Eng. 1994 7: 435-443; doi:10.1093/protein/7.3.435 [Abstract] [PDF] [Request Permissions]  

John N. Hope, Hao-Chia Chen, and J.Fidding Hejtmancik

ßA3/Al-crystallin association: role of the N-terminal arm
Protein Eng. 1994 7: 445-451; doi:10.1093/protein/7.3.445 [Abstract] [PDF] [Request Permissions]  

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