Protein Engineering Design and Selection

REVIEW:

Masakazu Kikuchi and Morio Ikehara

From genesis to function of proteins: investigation of general principles by engineering human lysozyme
Protein Eng. 1994 7: 735-742; doi:10.1093/protein/7.6.735 [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Taiji Imoto, Tadashi Ueda, Tomohiro Tamura, Yoshimasa Isakari, Yoshito Abe, Makoto Inoue, Takeyoshi Miki, Keiichi Kawano, and Hidenori Yamada

Lysozyme requires fluctuation of the active site for the manifestation of activity
Protein Eng. 1994 7: 743-748; doi:10.1093/protein/7.6.743 [Abstract] [PDF] [Request Permissions]  

Pedro M. Coutinho and Peter J. Reilly

Structural similarities in glucoamylases by hydrophobic cluster analysis
Protein Eng. 1994 7: 749-760; doi:10.1093/protein/7.6.749 [Abstract] [PDF] [Request Permissions]  

Ronald M.A Knegtel, Rolf Boelens, and Robert Kaptein

Monte Carlo docking of protein-DNA complexes: incorporation of DNA flexibility and experimental data
Protein Eng. 1994 7: 761-768; doi:10.1093/protein/7.6.761 [Abstract] [PDF] [Request Permissions]  

Danièle Altschuh, Daniel C. Tessier, and Thierry Vernet

Modulation of the enzymatic activity of papain by interdomain residues remote from the active site
Protein Eng. 1994 7: 769-776; doi:10.1093/protein/7.6.769 [Abstract] [PDF] [Request Permissions]  

Nadia F. elMasry and Alan R. Fersht

Mutational analysis of the N-capping box of the -helix of chymotrypsin inhibitor 2
Protein Eng. 1994 7: 777-782; doi:10.1093/protein/7.6.777 [Abstract] [PDF] [Request Permissions]  

Janette A. Thomas, John R.P. Arnold, Jaswir Basran, Julie Andrews, Gordon C.K. Roberts, Berry Birdsall, and James Feeney

Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase
Protein Eng. 1994 7: 783-792; doi:10.1093/protein/7.6.783 [Abstract] [PDF] [Request Permissions]  

Maarten R. Egmond, Willem P. Antheunisse, Carla J. van Bemmel, Peter Ravestein, Jacob de Vlieg, Hans Peters, and Sven Branner

Engineering surface charges in a subtilisin: the effects on electrophoretic and ion-exchange behaviour
Protein Eng. 1994 7: 793-800; doi:10.1093/protein/7.6.793 [Abstract] [PDF] [Request Permissions]  

Frank J.T. van der Bolt, Mathilde C. Drijfhout, Michel H.M. Eppink, Wilfred R. Hagen, and Willem J.H. van Berkel

Selective cysteine serine replacements in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens allow the unambiguous assignment of Cys211 as the site of modification by spin-labeled p-chloromercuribenzoate
Protein Eng. 1994 7: 801-804; doi:10.1093/protein/7.6.801 [Abstract] [PDF] [Request Permissions]  

Gary M. Studnicka, Sandra Soares, Marc Better, Robert E. Williams, Rossana Nadell, and Arnold H. Horwitz

Human-engineered monoclonal antibodies retain full specific binding activity by preserving non-CDR complementarity-modulating residues
Protein Eng. 1994 7: 805-814; doi:10.1093/protein/7.6.805 [Abstract] [PDF] [Request Permissions]  

Ku-chuan Hsiao, Jürgen Bajorath, and Linda J. Harris

Humanization of 60.3, an anti-CD18 antibody; importance of the L2 loop
Protein Eng. 1994 7: 815-822; doi:10.1093/protein/7.6.815 [Abstract] [PDF] [Request Permissions]  

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