Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Radha Kishan, Ph. Johan Zeelen, Martin E.M. Noble, Torben V. Borchert, Véronique Mainfroid, Karine Goraj, Joseph A. Martial, and Rik K. Wierenga

Modular mutagenesis of a TEM-barrel enzyme: the crystal structure of a chimeric E.coli TIM having the eighth ß-unit replaced by the equivalent unit of chicken TIM
Protein Eng. 1994 7: 945-951; doi:10.1093/protein/7.8.945 [Abstract] [PDF] [Request Permissions]  

Krzysztof Fidelis, Peter S. Stern, David Bacon, and John Moult

Comparison of systematic search and database methods for constructing segments of protein structure
Protein Eng. 1994 7: 953-960; doi:10.1093/protein/7.8.953 [Abstract] [PDF] [Request Permissions]  

Alex P. Korn and David R. Rose

Torsion angle differences as a means of pinpointing local polypeptide chain trajectory changes for identical proteins in different conformational states
Protein Eng. 1994 7: 961-967; doi:10.1093/protein/7.8.961 [Abstract] [PDF] [Request Permissions]  

Toshiki Tanaka, Yutaka Kuroda, Hiromi Kimura, Shun-ichi Kidokoro, and Haruki Nakamura

Cooperative deformation of a de novo designed protein
Protein Eng. 1994 7: 969-976; doi:10.1093/protein/7.8.969 [Abstract] [PDF] [Request Permissions]  

Roman Jerala, Eva Zerovnik, Karl Lohner, and Vito Turk

Structural basis for the difference in thermodynamic properties between the two cysteine proteinase inhibitors human stefins A and B
Protein Eng. 1994 7: 977-984; doi:10.1093/protein/7.8.977 [Abstract] [PDF] [Request Permissions]  

J.C. vanderSpek, K. Howland, T. Friedman, and J.R. Murphy

Maintenance of the hydrophobic face of the diphtheria toxin amphipathic transmembrane helix 1 is essential for the efficient delivery of the catalytic domain to the cytosol of target cells
Protein Eng. 1994 7: 985-989; doi:10.1093/protein/7.8.985 [Abstract] [PDF] [Request Permissions]  

Paul G. Bruinenberg, Paul Doesburg, Arno C. Alting, Fred A. Exterkate, Willem M.de Vos, and Roland J. Siezen

Evidence for a large dispensable segment in the subtilisin-like catalytic domain of the Lactococcus lactis cell-envelope proteinas
Protein Eng. 1994 7: 991-996; doi:10.1093/protein/7.8.991 [Abstract] [PDF] [Request Permissions]  

Nathalie Declerck and John Abelson

Novel substrate specificity engineered in the arabinose binding protein
Protein Eng. 1994 7: 997-1004; doi:10.1093/protein/7.8.997 [Abstract] [PDF] [Request Permissions]  

Nathalie Flory, Maureen Gorman, Pedro M. Coutinho, Clark Ford, and Peter J. Reilly

Thermosensitive mutants of Aspergillus awamori glucoamylase by random mutagenesis: inactivation kinetics and structural interpretation
Protein Eng. 1994 7: 1005-1012; doi:10.1093/protein/7.8.1005 [Abstract] [PDF] [Request Permissions]  

Xing-Guo Wang and Paul C. Engel

Identification of the reactive cysteine in clostridial glutamate dehydrogenase by site-directed mutagenesis and proof that this residue is not strictly essential
Protein Eng. 1994 7: 1013-1016; doi:10.1093/protein/7.8.1013 [Abstract] [PDF] [Request Permissions]  

Marc Whitlow, David Filpula, Michele L. Rollence, Sheau-Line Feng, and James F. Wood

Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv
Protein Eng. 1994 7: 1017-1026; doi:10.1093/protein/7.8.1017 [Abstract] [PDF] [Request Permissions]  

Dominique Desplancq, David J. King, Alastair D.G. Lawson, and Andrew Mountain

Multimerization behaviour of single chain Fv variants for the tumour-binding antibody B72.3
Protein Eng. 1994 7: 1027-1033; doi:10.1093/protein/7.8.1027 [Abstract] [PDF] [Request Permissions]  

Richard A. Williamson, Helga Bartels, Gillian Murphy, and Robert B. Freedman

Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2
Protein Eng. 1994 7: 1035-1040; doi:10.1093/protein/7.8.1035 [Abstract] [PDF] [Request Permissions]  

Violetta V. Chemeris, Dmitry A. Dolgikh, Alexey N. Fedorov, Alexey V. Finkelstein, Michail P. Kirpichnikov, Vladimir N. Uversky, and Oleg B. Ptitsyn

A new approach to artificial and modified proteins: theory-based design, synthesis in a cell-free system and fast testing of structural properties by radiolabels
Protein Eng. 1994 7: 1041-1052; doi:10.1093/protein/7.8.1041 [Abstract] [PDF] [Request Permissions]  

V. Ramesh, Amitabha De, and V. Nagaraja

Engineering hyperexpression of bacteriophage Mu C protein by removal of secondary structure at the translation initiation region
Protein Eng. 1994 7: 1053-1057; doi:10.1093/protein/7.8.1053 [Abstract] [PDF] [Request Permissions]  

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