Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Nai-Ming Chu, Yang Chao, and Ru-Chang Bi

The 2 Å crystal structure of subtilisin E with PMSF inhibitor
Protein Eng. 1995 8: 211-215; doi:10.1093/protein/8.3.211 [Abstract] [PDF] [Request Permissions]  

Ian K. MCDonald and Janet M. Thornton

The application of hydrogen bonding analysis in X-ray crystallography to help orientate asparagine, glutamine and histidine side chains
Protein Eng. 1995 8: 217-224; doi:10.1093/protein/8.3.217 [Abstract] [PDF] [Request Permissions]  

Mariusz Milik, Andrzej Kolinski, and Jeffrey Skolnick

Neural network system for the evaluation of side-chain packing in protein structures
Protein Eng. 1995 8: 225-236; doi:10.1093/protein/8.3.225 [Abstract] [PDF] [Request Permissions]  

Simon Delagrave, Ellen R. Goldman, and Douglas C. Youvan

Context dependence of phenotype prediction and diversity in combinatorial mutagenesis
Protein Eng. 1995 8: 237-242; doi:10.1093/protein/8.3.237 [Abstract] [PDF] [Request Permissions]  

Andrej Karshikoff

A simple algorithm for the calculation of multiple site titration curves
Protein Eng. 1995 8: 243-248; doi:10.1093/protein/8.3.243 [Abstract] [PDF] [Request Permissions]  

Annick Houbrechts, Benoît Moreau, Ruben Abagyan, Véronique Mainfroid, Gisèle Préaux, Alain Lamproye, Alain Poncin, Erik Goormaghtigh, Jean-Marie Ruysschaert, Joseph A. Martial, and Karine Goraj

Second-generation octarellins: two new de novo (ß/)₈ polypeptides designed for investigating the influence of ß-residue packing on the /ß-barrel structure stability
Protein Eng. 1995 8: 249-259; doi:10.1093/protein/8.3.249 [Abstract] [PDF] [Request Permissions]  

Stephen B. delCardayré, Marc Ribó, Erich M. Yokel, David J. Quirk, William J. Rutter, and Ronald T. Raines

Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11
Protein Eng. 1995 8: 261-273; doi:10.1093/protein/8.3.261 [Abstract] [PDF] [Request Permissions]  

David L. Sloane, Regina Leung, Jim Barnett, Charles S. Craik, and Elliott Sigal

Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity
Protein Eng. 1995 8: 275-282; doi:10.1093/protein/8.3.275 [Abstract] [PDF] [Request Permissions]  

Eva Wolf, Ivan Brukner, and Dietrich Suck

Mutational analysis of DNase I-DNA interactions: design, expression and characterization of a DNase I loop insertion mutant with altered sequence selectivity
Protein Eng. 1995 8: 283-291; doi:10.1093/protein/8.3.283 [Abstract] [PDF] [Request Permissions]  

Arjen H. F. Bakker, Edward F. Rehberg, Keith R. Marotti, and Jan H. Verheijen

The position of the structurally autonomous kringle 2 domain influences the functional features of tissue-type plasminogen activator
Protein Eng. 1995 8: 293-300; doi:10.1093/protein/8.3.293 [Abstract] [PDF] [Request Permissions]  

John E. McCartney, Mei-Sheng Tai, Robert M. Hudziak, Gregory P. Adams, Louis M. Weiner, Donald Jin, Walter F. Stafford, III, Sen Liu, Michael A. Bookman, Axel A. Laminet, Irwin Fand, L. L. Houston, Hermann Oppermann, and James S. Huston

Engineering disulfide-linked single-chain Fv dimers [(sFv')₂] with improved solution and targeting properties: anti-digoxin 26–10 (sFv')₂ and anti-c-erbB-2 741F8 (sFv')₂ made by protein folding and bonded through C-terminal cysteinyl peptides
Protein Eng. 1995 8: 301-314; doi:10.1093/protein/8.3.301 [Abstract] [PDF] [Request Permissions]  

V. M. Dhople and R. Nagaraj

Generation of analogs having potent antimicrobial and hemolytic activities with minimal changes from an inactive 16-residue peptide corresponding to the helical region of Staphylococcus aureus -toxin
Protein Eng. 1995 8: 315-318; doi:10.1093/protein/8.3.315 [Abstract] [PDF] [Request Permissions]  

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